Heat oven to 350℉/177℃.
Line a muffin tin with paper liners. Set aside.
In a medium bowl, whisk flour, cocoa powder, baking powder, and baking soda together. Set aside.
With an electric mixer, beat butter, sugar, and salt until light and fluffy, about 2-3 minutes.
Beat in food coloring.
Add egg and vanilla.
Beat until light and fluffy, about 1-2 minutes.
Mix in dry ingredients alternately with buttermilk, beginning and ending with dry ingredients.
Stir in vinegar.
Use a large (3 Tablespoon) cookie scoop to portion batter into prepared pan.
Insert 1 plug of frozen ganache in the center of each cupcake, pressing down into the batter.
Bake for 18-20 minutes, or until done.