Heat oven to 350℉/177℃.
Line muffin tins with paper liners, or spray with baking spray. Set aside.
In a large bowl, whisk together flour, sugar, baking powder, baking soda, salt, and spice.
In a medium bowl, whisk together buttermilk, pumpkin, oil, eggs, and vanilla.
Pour wet ingredients over dry ingredients.
Whisk until combined.
Use a 3 Tablespoon scoop to portion batter into muffin cups.
Insert 1 cream cheese ball into each muffin.
Sprinkle top with pumpkin seeds.
Bake for 30 minutes, or until muffins test done.